InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WAPAL

Summary

InnateDB Protein

IDBP-80909.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WAPAL

Protein Name

wings apart-like homolog (Drosophila)

Synonyms

FOE; KIAA0261; WAPL;

Species

Homo sapiens

Ensembl Protein

ENSP00000298767

InnateDB Gene

IDBG-80903 (WAPAL)

Protein Structure

UniProt Annotation

Function

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269PubMed:15150110, ECO:0000269PubMed:17112726, ECO:0000269PubMed:17113138, ECO:0000269PubMed:19696148, ECO:0000269PubMed:19907496, ECO:0000269PubMed:21111234, ECO:0000269PubMed:23776203}.

Subcellular Localization

Isoform 2: Nucleus.Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.

Disease Associations

Tissue Specificity

Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart. {ECO:0000269PubMed:15150110, ECO:0000269PubMed:15383329}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	37 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0008156	negative regulation of DNA replication
GO:0009636	response to toxic substance
GO:0016032	viral process
GO:0035562	negative regulation of chromatin binding
GO:0045875	negative regulation of sister chromatid cohesion
GO:0048146	positive regulation of fibroblast proliferation
GO:0051983	regulation of chromosome segregation
GO:0060623	regulation of chromosome condensation
GO:0071168	protein localization to chromatin
GO:0071922	regulation of cohesin localization to chromatin

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000785	chromatin
GO:0000795	synaptonemal complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0008278	cohesin complex
GO:0015630	microtubule cytoskeleton
GO:0043231	intracellular membrane-bounded organelle