InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTGR1

Summary

InnateDB Protein

IDBP-80925.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTGR1

Protein Name

prostaglandin reductase 1

Synonyms

LTB4DH; PGR1; ZADH3;

Species

Homo sapiens

Ensembl Protein

ENSP00000311572

InnateDB Gene

IDBG-80921 (PTGR1)

Protein Structure

UniProt Annotation

Function

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

High expression in the kidney, liver, and intestine but not in leukocytes. {ECO:0000269PubMed:8576264}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0032440	2-alkenal reductase [NAD(P)] activity
GO:0036132	13-prostaglandin reductase activity
GO:0047522	15-oxoprostaglandin 13-oxidase activity

Biological Process

GO:0006691	leukotriene metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019371	cyclooxygenase pathway
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:2001300	lipoxin metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR014190 Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14914