InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HAO2

Summary

InnateDB Protein

IDBP-809284.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAO2

Protein Name

hydroxyacid oxidase 2 (long chain)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000483507

InnateDB Gene

IDBG-101490 (HAO2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003973	(S)-2-hydroxy-acid oxidase activity
GO:0005102	receptor binding
GO:0010181	FMN binding
GO:0015930	glutamate synthase activity
GO:0016491	oxidoreductase activity
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0052852	very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052853	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052854	medium-chain-(S)-2-hydroxy-acid oxidase activity

Biological Process

GO:0006537	glutamate biosynthetic process
GO:0018924	mandelate metabolic process
GO:0019395	fatty acid oxidation
GO:0051260	protein homooligomerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000262 FMN-dependent dehydrogenase
IPR001093 IMP dehydrogenase/GMP reductase
IPR002932 Glutamate synthase domain
IPR012133 Alpha-hydroxy acid dehydrogenase, FMN-dependent

PFAM

PF01070
PF00478
PF01645

PRINTS

PIRSF

PIRSF000138

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite