Version 5.4
Homo sapiens Gene: HAO2
Summary
InnateDB Gene IDBG-101490.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAO2
Gene Name hydroxyacid oxidase 2 (long chain)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000116882
Encoded Proteins
IDBP-101492
hydroxyacid oxidase 2 (long chain)
IDBP-101496
hydroxyacid oxidase 2 (long chain)
IDBP-387917
hydroxyacid oxidase 2 (long chain)
IDBP-809284
hydroxyacid oxidase 2 (long chain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed predominantly in liver and kidney and has the highest activity toward the substrate 2-hydroxypalmitate. Two alternatively spliced variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:119368779-119394130
Strand Forward strand
Band p12
Transcripts
ENST00000361035 ENSP00000354314
ENST00000325945 ENSP00000316339
ENST00000457318 ENSP00000393955
ENST00000482991
ENST00000622548 ENSP00000483507
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0005102 receptor binding
GO:0010181 FMN binding
GO:0015930 glutamate synthase activity
GO:0016491 oxidoreductase activity
GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0052852 very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052853 long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052854 medium-chain-(S)-2-hydroxy-acid oxidase activity
Biological Process
GO:0006537 glutamate biosynthetic process
GO:0018924 mandelate metabolic process
GO:0019395 fatty acid oxidation
GO:0051260 protein homooligomerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027870
View Gene Order
ENSBTAG00000000123
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.659767
RefSeq NM_001005783 NM_016527
HUGO
OMIM
CCDS CCDS901
HPRD 05532
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca