InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOA2

Summary

InnateDB Protein

IDBP-809592.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOA2

Protein Name

apolipoprotein A-II

Synonyms

Apo-AII; ApoA-II; apoAII;

Species

Homo sapiens

Ensembl Protein

ENSP00000476911

InnateDB Gene

IDBG-104234 (APOA2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008289	lipid binding
GO:0015485	cholesterol binding
GO:0017127	cholesterol transporter activity
GO:0031210	phosphatidylcholine binding
GO:0034190	apolipoprotein receptor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0055102	lipase inhibitor activity
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070653	high-density lipoprotein particle receptor binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0002740	negative regulation of cytokine secretion involved in immune response
GO:0006457	protein folding
GO:0006641	triglyceride metabolic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006869	lipid transport
GO:0007603	phototransduction, visible light
GO:0009395	phospholipid catabolic process
GO:0009749	response to glucose
GO:0010873	positive regulation of cholesterol esterification
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling
GO:0016032	viral process
GO:0018158	protein oxidation
GO:0018206	peptidyl-methionine modification
GO:0031647	regulation of protein stability
GO:0032375	negative regulation of cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034370	triglyceride-rich lipoprotein particle remodeling
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034380	high-density lipoprotein particle assembly
GO:0034384	high-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0043085	positive regulation of catalytic activity
GO:0043691	reverse cholesterol transport
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0046340	diacylglycerol catabolic process
GO:0050995	negative regulation of lipid catabolic process
GO:0050996	positive regulation of lipid catabolic process
GO:0060192	negative regulation of lipase activity
GO:0060621	negative regulation of cholesterol import
GO:0060695	negative regulation of cholesterol transporter activity

Cellular Component

GO:0005576	extracellular region
GO:0005769	early endosome
GO:0005788	endoplasmic reticulum lumen
GO:0005829	cytosol
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle