InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APOA2

Summary

InnateDB Gene

IDBG-104234.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOA2

Gene Name

apolipoprotein A-II

Synonyms

Apo-AII; ApoA-II; apoAII

Species

Homo sapiens

Ensembl Gene

ENSG00000158874

Encoded Proteins

IDBP-104236

apolipoprotein A-II

IDBP-809585

apolipoprotein A-II

IDBP-809586

apolipoprotein A-II

IDBP-809587

apolipoprotein A-II

IDBP-809589

apolipoprotein A-II

IDBP-809592

apolipoprotein A-II

IDBP-809594

apolipoprotein A-II

IDBP-809598

apolipoprotein A-II

IDBP-809595

apolipoprotein A-II

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:161222292-161223631

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000367990	ENSP00000356969
ENST00000481413
ENST00000468465	ENSP00000476662
ENST00000463812	ENSP00000476890
ENST00000481511	ENSP00000477054
ENST00000470459	ENSP00000477031
ENST00000464492	ENSP00000476911
ENST00000491350	ENSP00000477353
ENST00000469730	ENSP00000476605
ENST00000463273	ENSP00000476740

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005319	lipid transporter activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008035	high-density lipoprotein particle binding
GO:0008289	lipid binding
GO:0015485	cholesterol binding
GO:0017127	cholesterol transporter activity
GO:0031210	phosphatidylcholine binding
GO:0034190	apolipoprotein receptor binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0055102	lipase inhibitor activity
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070653	high-density lipoprotein particle receptor binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0002526	acute inflammatory response
GO:0002740	negative regulation of cytokine secretion involved in immune response
GO:0006457	protein folding
GO:0006641	triglyceride metabolic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006869	lipid transport
GO:0007603	phototransduction, visible light
GO:0008203	cholesterol metabolic process
GO:0009395	phospholipid catabolic process
GO:0009749	response to glucose
GO:0010873	positive regulation of cholesterol esterification
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling
GO:0016032	viral process
GO:0018158	protein oxidation
GO:0018206	peptidyl-methionine modification
GO:0030300	regulation of intestinal cholesterol absorption
GO:0030301	cholesterol transport
GO:0031100	organ regeneration
GO:0031647	regulation of protein stability
GO:0032375	negative regulation of cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034370	triglyceride-rich lipoprotein particle remodeling
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034380	high-density lipoprotein particle assembly
GO:0034384	high-density lipoprotein particle clearance
GO:0042157	lipoprotein metabolic process
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0043085	positive regulation of catalytic activity
GO:0043627	response to estrogen
GO:0043691	reverse cholesterol transport
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0046340	diacylglycerol catabolic process
GO:0050995	negative regulation of lipid catabolic process
GO:0050996	positive regulation of lipid catabolic process
GO:0051384	response to glucocorticoid
GO:0060192	negative regulation of lipase activity
GO:0060621	negative regulation of cholesterol import
GO:0060695	negative regulation of cholesterol transporter activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005788	endoplasmic reticulum lumen
GO:0005829	cytosol
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle