InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RQCD1

Summary

InnateDB Protein

IDBP-81035.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RQCD1

Protein Name

RCD1 required for cell differentiation1 homolog (S. pombe)

Synonyms

CNOT9; CT129; RCD-1; RCD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000273064

InnateDB Gene

IDBG-81033 (RQCD1)

Protein Structure

UniProt Annotation

Function

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. {ECO:0000250, ECO:0000269PubMed:17189474, ECO:0000269PubMed:18180299}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in spleen, thymus, prostate, testis, ovary and intestine. {ECO:0000269PubMed:9447985}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	34 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006417	regulation of translation
GO:0007548	sex differentiation
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0031047	gene silencing by RNA
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity