Version 5.4
Homo sapiens Gene: RQCD1
Summary
InnateDB Gene IDBG-81033.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RQCD1
Gene Name RCD1 required for cell differentiation1 homolog (S. pombe)
Synonyms CNOT9; CT129; RCD-1; RCD1
Species Homo sapiens
Ensembl Gene ENSG00000144580
Encoded Proteins
IDBP-81035
RCD1 required for cell differentiation1 homolog (S. pombe)
IDBP-81037
RCD1 required for cell differentiation1 homolog (S. pombe)
IDBP-388916
RCD1 required for cell differentiation1 homolog (S. pombe)
IDBP-388917
RCD1 required for cell differentiation1 homolog (S. pombe)
IDBP-388918
RCD1 required for cell differentiation1 homolog (S. pombe)
IDBP-603594
RCD1 required for cell differentiation1 homolog (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:218568580-218597080
Strand Forward strand
Band q35
Transcripts
ENST00000273064 ENSP00000273064
ENST00000295701 ENSP00000295701
ENST00000433439 ENSP00000415607
ENST00000432877 ENSP00000392394
ENST00000418808 ENSP00000396938
ENST00000489687
ENST00000473626
ENST00000542068 ENSP00000443687
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 34 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006417 regulation of translation
GO:0007548 sex differentiation
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0031047 gene silencing by RNA
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026174
View Gene Order
ENSBTAG00000003807
Not yet available
Pathways
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt Q92600
TrEMBL B4DJE1 D5MQE1
UniProt Splice Variant
Entrez Gene 9125
UniGene Hs.148767 Hs.699959 Hs.703862 Hs.732405
RefSeq NM_001271634 NM_001271635 NM_005444 XM_005246942 XM_005246943 XM_006712832
HUGO HGNC:10445
OMIM 612054
CCDS CCDS33379 CCDS63123
HPRD 08828
IMGT
EMBL AB500892 AC012510 AK293281 AK296037 BC007102 BC137455 BC137456 CH471063 D87957
GenPept AAH07102 AAI37456 AAI37457 BAA13508 BAG58803 BAH11481 BAJ07307 EAW70625
RNA Seq Atlas 9125

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca