Version 5.4
Homo sapiens Protein: CDK5
Summary
InnateDB Protein IDBP-810597.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK5
Protein Name cyclin-dependent kinase 5
Synonyms PSSALRE;
Species Homo sapiens
Ensembl Protein ENSP00000481070
InnateDB Gene IDBG-48977 (CDK5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 98 [view]
Protein-Protein 97 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005176 ErbB-2 class receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030549 acetylcholine receptor activator activity
GO:0043125 ErbB-3 class receptor binding
GO:0050321 tau-protein kinase activity
Biological Process
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0007416 synapse assembly
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0009790 embryo development
GO:0016079 synaptic vesicle exocytosis
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0030182 neuron differentiation
GO:0031175 neuron projection development
GO:0042981 regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048167 regulation of synaptic plasticity
GO:0048488 synaptic vesicle endocytosis
GO:0048511 rhythmic process
GO:0048675 axon extension
GO:0048709 oligodendrocyte differentiation
GO:0051301 cell division
GO:0051402 neuron apoptotic process
GO:0061001 regulation of dendritic spine morphogenesis
GO:0071156 regulation of cell cycle arrest
GO:1901215 negative regulation of neuron death
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000273 positive regulation of receptor activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031594 neuromuscular junction
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 1020
UniGene
RefSeq
HUGO HGNC:1774
OMIM 123831
CCDS
HPRD
IMGT
EMBL AC010973 AY049778 BC005115 BT006680 DQ411039 X66364
GenPept AAH05115 AAL15435 AAP35326 ABD66016 CAA47007

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca