InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDK5

Summary

InnateDB Gene

IDBG-48977.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK5

Gene Name

cyclin-dependent kinase 5

Synonyms

PSSALRE

Species

Homo sapiens

Ensembl Gene

ENSG00000164885

Encoded Proteins

IDBP-48979

cyclin-dependent kinase 5

IDBP-482107

cyclin-dependent kinase 5

IDBP-810597

cyclin-dependent kinase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:151053812-151058530

Strand

Reverse strand

Band

q36.1

Transcripts

ENST00000297518	ENSP00000297518
ENST00000485972	ENSP00000419782
ENST00000487703
ENST00000476691
ENST00000469108
ENST00000618146	ENSP00000481070

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	97 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005176	ErbB-2 class receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008092	cytoskeletal protein binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030549	acetylcholine receptor activator activity
GO:0043125	ErbB-3 class receptor binding
GO:0046875	ephrin receptor binding
GO:0050321	tau-protein kinase activity

Biological Process

GO:0001764	neuron migration
GO:0001963	synaptic transmission, dopaminergic
GO:0006468	protein phosphorylation
GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0006913	nucleocytoplasmic transport
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0007160	cell-matrix adhesion
GO:0007268	synaptic transmission
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007416	synapse assembly
GO:0007519	skeletal muscle tissue development
GO:0007596	blood coagulation
GO:0008045	motor neuron axon guidance
GO:0008283	cell proliferation
GO:0008306	associative learning
GO:0008542	visual learning
GO:0009611	response to wounding
GO:0009790	embryo development
GO:0014044	Schwann cell development
GO:0016079	synaptic vesicle exocytosis
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0019233	sensory perception of pain
GO:0021537	telencephalon development
GO:0021549	cerebellum development
GO:0021695	cerebellar cortex development
GO:0021697	cerebellar cortex formation
GO:0021766	hippocampus development
GO:0021819	layer formation in cerebral cortex
GO:0021954	central nervous system neuron development
GO:0021987	cerebral cortex development
GO:0022038	corpus callosum development
GO:0030182	neuron differentiation
GO:0030334	regulation of cell migration
GO:0030517	negative regulation of axon extension
GO:0030866	cortical actin cytoskeleton organization
GO:0030900	forebrain development
GO:0031175	neuron projection development
GO:0031397	negative regulation of protein ubiquitination
GO:0031914	negative regulation of synaptic plasticity
GO:0032092	positive regulation of protein binding
GO:0032801	receptor catabolic process
GO:0033136	serine phosphorylation of STAT3 protein
GO:0035249	synaptic transmission, glutamatergic
GO:0035418	protein localization to synapse
GO:0042220	response to cocaine
GO:0042981	regulation of apoptotic process
GO:0043113	receptor clustering
GO:0043525	positive regulation of neuron apoptotic process
GO:0045055	regulated secretory pathway
GO:0045786	negative regulation of cell cycle
GO:0045860	positive regulation of protein kinase activity
GO:0045861	negative regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0046777	protein autophosphorylation
GO:0046826	negative regulation of protein export from nucleus
GO:0048148	behavioral response to cocaine
GO:0048167	regulation of synaptic plasticity
GO:0048488	synaptic vesicle endocytosis
GO:0048511	rhythmic process
GO:0048675	axon extension
GO:0048709	oligodendrocyte differentiation
GO:0048812	neuron projection morphogenesis
GO:0048813	dendrite morphogenesis
GO:0051301	cell division
GO:0051402	neuron apoptotic process
GO:0060078	regulation of postsynaptic membrane potential
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0061001	regulation of dendritic spine morphogenesis
GO:0070509	calcium ion import
GO:0071156	regulation of cell cycle arrest
GO:0090314	positive regulation of protein targeting to membrane
GO:1901215	negative regulation of neuron death
GO:2000251	positive regulation of actin cytoskeleton reorganization
GO:2000273	positive regulation of receptor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030175	filopodium
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031594	neuromuscular junction
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0045211	postsynaptic membrane