InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SARM1

Summary

InnateDB Protein

IDBP-810781.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SARM1

Protein Name

sterile alpha and TIR motif containing 1

Synonyms

MyD88-5; SAMD2; SARM;

Species

Homo sapiens

Ensembl Protein

ENSP00000468032

InnateDB Gene

IDBG-36569 (SARM1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0007165	signal transduction
GO:0009749	response to glucose
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0048814	regulation of dendrite morphogenesis
GO:1901214	regulation of neuron death

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005874	microtubule
GO:0015630	microtubule cytoskeleton
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0031315	extrinsic component of mitochondrial outer membrane
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR016024 Armadillo-type fold
IPR021129 Sterile alpha motif, type 1

PFAM

PF01582
PF13676
PF07647
PF00536

PRINTS

PIRSF

SMART

SM00255
SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6SZW1