InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIG4

Summary

InnateDB Protein

IDBP-810813.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIG4

Protein Name

ligase IV, DNA, ATP-dependent

Synonyms

LIG4S;

Species

Homo sapiens

Ensembl Protein

ENSP00000484288

InnateDB Gene

IDBG-49744 (LIG4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 160 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	160 [view]
Protein-Protein	160 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0000012	single strand break repair
GO:0001701	in utero embryonic development
GO:0002328	pro-B cell differentiation
GO:0006266	DNA ligation
GO:0006273	lagging strand elongation
GO:0006281	DNA repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0007049	cell cycle
GO:0007417	central nervous system development
GO:0008283	cell proliferation
GO:0010165	response to X-ray
GO:0010212	response to ionizing radiation
GO:0010332	response to gamma radiation
GO:0016032	viral process
GO:0033077	T cell differentiation in thymus
GO:0033151	V(D)J recombination
GO:0033152	immunoglobulin V(D)J recombination
GO:0033153	T cell receptor V(D)J recombination
GO:0035019	somatic stem cell maintenance
GO:0043524	negative regulation of neuron apoptotic process
GO:0045190	isotype switching
GO:0048146	positive regulation of fibroblast proliferation
GO:0050769	positive regulation of neurogenesis
GO:0051102	DNA ligation involved in DNA recombination
GO:0051103	DNA ligation involved in DNA repair
GO:0051276	chromosome organization
GO:0051301	cell division
GO:0051402	neuron apoptotic process
GO:0071285	cellular response to lithium ion
GO:0071897	DNA biosynthetic process
GO:0075713	establishment of integrated proviral latency

Cellular Component

GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
GO:0032807	DNA ligase IV complex
GO:0070419	nonhomologous end joining complex

Protein Structure and Domains

PDB ID

InterPro

IPR000977 DNA ligase, ATP-dependent
IPR001357 BRCT domain
IPR012308 DNA ligase, ATP-dependent, N-terminal
IPR012309 DNA ligase, ATP-dependent, C-terminal
IPR012310 DNA ligase, ATP-dependent, central
IPR012340 Nucleic acid-binding, OB-fold
IPR021536 DNA ligase IV domain

PFAM

PF00533
PF12738
PF04675
PF04679
PF01068
PF11411

PRINTS

PIRSF

SMART

SM00292

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite