InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LIG4

Summary

InnateDB Gene

IDBG-49744.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIG4

Gene Name

ligase IV, DNA, ATP-dependent

Synonyms

LIG4S

Species

Homo sapiens

Ensembl Gene

ENSG00000174405

Encoded Proteins

IDBP-49748

ligase IV, DNA, ATP-dependent

IDBP-293708

ligase IV, DNA, ATP-dependent

IDBP-373332

ligase IV, DNA, ATP-dependent

IDBP-810813

ligase IV, DNA, ATP-dependent

IDBP-810815

ligase IV, DNA, ATP-dependent

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:108207439-108218368

Strand

Reverse strand

Band

q33.3

Transcripts

ENST00000356922	ENSP00000349393
ENST00000405925	ENSP00000385955
ENST00000442234	ENSP00000402030
ENST00000611712	ENSP00000484288
ENST00000614526	ENSP00000480814

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 160 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	160 [view]
Protein-Protein	160 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0000012	single strand break repair
GO:0001701	in utero embryonic development
GO:0002328	pro-B cell differentiation
GO:0006266	DNA ligation
GO:0006273	lagging strand elongation
GO:0006281	DNA repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0007049	cell cycle
GO:0007417	central nervous system development
GO:0008283	cell proliferation
GO:0010165	response to X-ray
GO:0010212	response to ionizing radiation
GO:0010332	response to gamma radiation
GO:0016032	viral process
GO:0033077	T cell differentiation in thymus
GO:0033151	V(D)J recombination
GO:0033152	immunoglobulin V(D)J recombination
GO:0033153	T cell receptor V(D)J recombination
GO:0035019	somatic stem cell maintenance
GO:0043524	negative regulation of neuron apoptotic process
GO:0045190	isotype switching
GO:0048146	positive regulation of fibroblast proliferation
GO:0050769	positive regulation of neurogenesis
GO:0051102	DNA ligation involved in DNA recombination
GO:0051103	DNA ligation involved in DNA repair
GO:0051276	chromosome organization
GO:0051301	cell division
GO:0051402	neuron apoptotic process
GO:0071285	cellular response to lithium ion
GO:0071897	DNA biosynthetic process
GO:0075713	establishment of integrated proviral latency

Cellular Component

GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
GO:0032807	DNA ligase IV complex
GO:0070419	nonhomologous end joining complex