InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYSLTR1

Summary

InnateDB Protein

IDBP-810858.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYSLTR1

Protein Name

cysteinyl leukotriene receptor 1

Synonyms

CYSLT1; CYSLT1R; CYSLTR; HMTMF81;

Species

Homo sapiens

Ensembl Protein

ENSP00000478492

InnateDB Gene

IDBG-78021 (CYSLTR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004974	leukotriene receptor activity
GO:0005515	protein binding

Biological Process

GO:0006816	calcium ion transport
GO:0006935	chemotaxis
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007585	respiratory gaseous exchange
GO:0045766	positive regulation of angiogenesis
GO:0045907	positive regulation of vasoconstriction

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR004071 Cysteinyl leukotriene receptor
IPR013310 Cysteinyl leukotriene receptor 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019427 7TM GPCR, serpentine receptor class w (Srw)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10323
PF10324
PF10328

PRINTS

PR00237
PR01533
PR01902

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite