InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: E2F8

Summary

InnateDB Protein

IDBP-811267.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2F8

Protein Name

E2F transcription factor 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000481103

InnateDB Gene

IDBG-35571 (E2F8)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001890	placenta development
GO:0002040	sprouting angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008283	cell proliferation
GO:0032466	negative regulation of cytokinesis
GO:0032877	positive regulation of DNA endoreduplication
GO:0033301	cell cycle comprising mitosis without cytokinesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060707	trophoblast giant cell differentiation
GO:0060718	chorionic trophoblast cell differentiation
GO:0070365	hepatocyte differentiation