InnateDB Protein
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IDBP-81149.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SNCG
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Protein Name
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synuclein, gamma (breast cancer-specific protein 1)
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Synonyms
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BCSG1; SR;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000361087
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InnateDB Gene
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IDBG-81145 (SNCG)
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Protein Structure
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Function |
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, perinuclear region {ECO:0000269PubMed:11746666}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:11746666}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:11746666}. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
29
[view]
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Protein-Protein |
29
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001058
Synuclein
IPR002462
Gamma-synuclein
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PFAM |
PF01387
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PRINTS |
PR01211
PR01214
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O76070
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PhosphoSite |
PhosphoSite-O76070
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TrEMBL |
Q6FHG5
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UniProt Splice Variant |
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Entrez Gene |
6623
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UniGene |
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RefSeq |
NP_003078
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HUGO |
HGNC:11141
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OMIM |
602998
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CCDS |
CCDS7380
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HPRD |
04297
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IMGT |
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EMBL |
AF010126
AF017256
AF037207
AF044311
AF411524
AK223367
AK312141
BC014098
CH471142
CR541788
CR541790
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GenPept |
AAB64109
AAC27738
AAC36550
AAC36586
AAH14098
AAL05870
BAD97087
BAG35077
CAG46587
CAG46589
EAW80316
EAW80317
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