InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP2B1

Summary

InnateDB Protein

IDBP-811532.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP2B1

Protein Name

adaptor-related protein complex 2, beta 1 subunit

Synonyms

ADTB2; AP105B; AP2-BETA; CLAPB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000482315

InnateDB Gene

IDBG-41836 (AP2B1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	97 [view]
Protein-Protein	96 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0030276	clathrin binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0015031	protein transport
GO:0016032	viral process
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050690	regulation of defense response to virus by virus

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030131	clathrin adaptor complex
GO:0030666	endocytic vesicle membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000225 Armadillo
IPR000357 HEAT
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR015151 Beta-adaptin appendage, C-terminal subdomain
IPR016024 Armadillo-type fold
IPR016342 AP-1, 2,4 complex subunit beta

PFAM

PF00514
PF02985
PF01602
PF02883
PF09066

PRINTS

PIRSF

PIRSF002291

SMART

SM00185
SM00809
SM01020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt