Version 5.4
Homo sapiens Gene: AP2B1
Summary
InnateDB Gene IDBG-41836.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP2B1
Gene Name adaptor-related protein complex 2, beta 1 subunit
Synonyms ADTB2; AP105B; AP2-BETA; CLAPB1
Species Homo sapiens
Ensembl Gene ENSG00000006125
Encoded Proteins
IDBP-763326
IDBP-760312
IDBP-764281
IDBP-760058
IDBP-759513
IDBP-759601
IDBP-762663
IDBP-758043
IDBP-811524
adaptor-related protein complex 2, beta 1 subunit
IDBP-811532
adaptor-related protein complex 2, beta 1 subunit
IDBP-811536
adaptor-related protein complex 2, beta 1 subunit
IDBP-811539
adaptor-related protein complex 2, beta 1 subunit
IDBP-811543
adaptor-related protein complex 2, beta 1 subunit
IDBP-811547
adaptor-related protein complex 2, beta 1 subunit
IDBP-811548
adaptor-related protein complex 2, beta 1 subunit
IDBP-811549
adaptor-related protein complex 2, beta 1 subunit
IDBP-811551
adaptor-related protein complex 2, beta 1 subunit
IDBP-811558
adaptor-related protein complex 2, beta 1 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35578046-35726409
Strand Forward strand
Band q12
Transcripts
ENST00000592167 ENSP00000467382
ENST00000590432 ENSP00000465357
ENST00000588093
ENST00000593014 ENSP00000466812
ENST00000591610 ENSP00000465848
ENST00000589774 ENSP00000468183
ENST00000590538 ENSP00000468813
ENST00000588116 ENSP00000464966
ENST00000587805 ENSP00000466580
ENST00000591561
ENST00000616784 ENSP00000478471
ENST00000621914 ENSP00000482315
ENST00000621668 ENSP00000481704
ENST00000616681 ENSP00000484708
ENST00000620039 ENSP00000481246
ENST00000612035 ENSP00000482825
ENST00000610402 ENSP00000483185
ENST00000614600 ENSP00000479691
ENST00000612116 ENSP00000478115
ENST00000619183
ENST00000618940 ENSP00000482835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 97 [view]
Protein-Protein 96 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:0030276 clathrin binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007411 axon guidance
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050690 regulation of defense response to virus by virus
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030131 clathrin adaptor complex
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000035152
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_11200
Nef Mediated CD8 Down-regulation pathway
REACT_11166
Nef Mediated CD4 Down-regulation pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_172581
PCP/CE pathway pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_172599
WNT5A-dependent internalization of FZD4 pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_6185
HIV Infection pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
KEGG
hsa04144
Endocytosis pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001030006 NM_001282 XM_005257941
HUGO
OMIM
CCDS CCDS32621 CCDS32622
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca