InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKAG3

Summary

InnateDB Protein

IDBP-81162.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKAG3

Protein Name

protein kinase, AMP-activated, gamma 3 non-catalytic subunit

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000233944

InnateDB Gene

IDBG-81160 (PRKAG3)

Protein Structure

UniProt Annotation

Function

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. {ECO:0000269PubMed:14722619}.

Subcellular Localization

Disease Associations

Tissue Specificity

Skeletal muscle, with weak expression in heart and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004679	AMP-activated protein kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0019901	protein kinase binding
GO:0030554	adenyl nucleotide binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006633	fatty acid biosynthetic process
GO:0007050	cell cycle arrest
GO:0008286	insulin receptor signaling pathway
GO:0016310	phosphorylation
GO:0035556	intracellular signal transduction
GO:0061024	membrane organization