Version 5.4
Homo sapiens Protein: POLA1
Summary
InnateDB Protein IDBP-811683.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLA1
Protein Name polymerase (DNA directed), alpha 1, catalytic subunit
Synonyms NSX; p180; POLA;
Species Homo sapiens
Ensembl Protein ENSP00000478401
InnateDB Gene IDBG-53117 (POLA1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 48 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
IPR006172 DNA-directed DNA polymerase, family B
IPR012337 Ribonuclease H-like domain
IPR015088 Zinc finger, DNA-directed DNA polymerase, family B, alpha
IPR024647 DNA polymerase alpha catalytic subunit, N-terminal domain
PFAM PF03104
PF00136
PF08996
PF12254
PRINTS PR00106
PIRSF
SMART SM00486
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 5422
UniGene
RefSeq
HUGO HGNC:9173
OMIM 312040
CCDS
HPRD
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca