InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: POLA1

Summary

InnateDB Gene

IDBG-53117.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLA1

Gene Name

polymerase (DNA directed), alpha 1, catalytic subunit

Synonyms

NSX; p180; POLA

Species

Homo sapiens

Ensembl Gene

ENSG00000101868

Encoded Proteins

IDBP-53119

polymerase (DNA directed), alpha 1, catalytic subunit

IDBP-53121

polymerase (DNA directed), alpha 1, catalytic subunit

IDBP-811683

polymerase (DNA directed), alpha 1, catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:24693919-24996986

Strand

Forward strand

Band

p22.11

Transcripts

ENST00000379068	ENSP00000368358
ENST00000379059	ENSP00000368349
ENST00000493342
ENST00000480125
ENST00000494204
ENST00000611764	ENSP00000478401

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	48 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001882	nucleoside binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0003896	DNA primase activity
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000084	mitotic S phase
GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006261	DNA-dependent DNA replication
GO:0006269	DNA replication, synthesis of RNA primer
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006272	leading strand elongation
GO:0006273	lagging strand elongation
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0008283	cell proliferation
GO:0016032	viral process
GO:0019985	translesion synthesis
GO:0032201	telomere maintenance via semi-conservative replication
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005658	alpha DNA polymerase:primase complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016363	nuclear matrix