InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHOH

Summary

InnateDB Protein

IDBP-812432.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHOH

Protein Name

ras homolog family member H

Synonyms

ARHH; TTF;

Species

Homo sapiens

Ensembl Protein

ENSP00000481566

InnateDB Gene

IDBG-14849 (RHOH)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005095	GTPase inhibitor activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0017048	Rho GTPase binding
GO:0019210	kinase inhibitor activity

Biological Process

GO:0006184	GTP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030217	T cell differentiation
GO:0042326	negative regulation of phosphorylation
GO:0043086	negative regulation of catalytic activity
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt