Version 5.4
Homo sapiens Gene: RHOH
Summary
InnateDB Gene IDBG-14849.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOH
Gene Name ras homolog family member H
Synonyms ARHH; TTF
Species Homo sapiens
Ensembl Gene ENSG00000168421
Encoded Proteins
IDBP-14853
ras homolog gene family, member H
IDBP-478882
ras homolog gene family, member H
IDBP-475433
ras homolog gene family, member H
IDBP-479813
ras homolog gene family, member H
IDBP-475842
ras homolog gene family, member H
IDBP-479930
ras homolog gene family, member H
IDBP-812432
ras homolog family member H
IDBP-812433
ras homolog family member H
IDBP-812434
ras homolog family member H
IDBP-812435
ras homolog family member H
IDBP-812436
ras homolog family member H
IDBP-812437
ras homolog family member H
IDBP-812438
ras homolog family member H
IDBP-812439
ras homolog family member H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Ras superfamily of small GTPases. Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. This gene encodes a small G-like protein, and unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin\'s lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5\' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:40191053-40246967
Strand Forward strand
Band p14
Transcripts
ENST00000381799 ENSP00000371219
ENST00000505618 ENSP00000425010
ENST00000507851 ENSP00000423384
ENST00000503754
ENST00000508513 ENSP00000422241
ENST00000511967
ENST00000503941 ENSP00000426439
ENST00000514839
ENST00000513894
ENST00000515702
ENST00000515718
ENST00000515503
ENST00000514143
ENST00000504638
ENST00000511121 ENSP00000420866
ENST00000503978
ENST00000615577 ENSP00000481566
ENST00000613272 ENSP00000480772
ENST00000617441 ENSP00000482947
ENST00000622175 ENSP00000481836
ENST00000619474 ENSP00000481746
ENST00000615083 ENSP00000480379
ENST00000610353 ENSP00000480192
ENST00000614836 ENSP00000478248
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0017048 Rho GTPase binding
GO:0019210 kinase inhibitor activity
Biological Process
GO:0006184 GTP catabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0030217 T cell differentiation
GO:0042326 negative regulation of phosphorylation
GO:0043086 negative regulation of catalytic activity
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045576 mast cell activation
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0001772 immunological synapse
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029204
View Gene Order
ENSBTAG00000013451
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04670
Leukocyte transendothelial migration pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.738915
RefSeq NM_001278359 NM_001278360 NM_001278361 NM_001278362 NM_001278363 NM_001278364 NM_001278365 NM_001278366 NM_001278367 NM_001278368 NM_001278369 NM_004310
HUGO
OMIM
CCDS CCDS3458
HPRD 03616
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca