Version 5.4
Homo sapiens Protein: POLR2A
Summary
InnateDB Protein IDBP-812578.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR2A
Protein Name polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Synonyms hRPB220; hsRPB1; POLR2; POLRA; RPB1; RPBh1; RpIILS; RPO2; RPOL2;
Species Homo sapiens
Ensembl Protein ENSP00000480158
InnateDB Gene IDBG-25255 (POLR2A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 435 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 435 [view]
Protein-Protein 304 [view]
Protein-DNA 131 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0005665 DNA-directed RNA polymerase II, core complex
Protein Structure and Domains
PDB ID
InterPro IPR000684 RNA polymerase II, heptapeptide repeat, eukaryotic
IPR000722 RNA polymerase, alpha subunit
IPR006592 RNA polymerase, N-terminal
IPR007066 RNA polymerase Rpb1, domain 3
IPR007073 RNA polymerase Rpb1, domain 7
IPR007075 RNA polymerase Rpb1, domain 6
IPR007080 RNA polymerase Rpb1, domain 1
IPR007081 RNA polymerase Rpb1, domain 5
IPR007083 RNA polymerase Rpb1, domain 4
PFAM PF05001
PF00623
PF04983
PF04990
PF04992
PF04997
PF04998
PF05000
PRINTS
PIRSF
SMART SM00663
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 5430
UniGene
RefSeq
HUGO HGNC:9187
OMIM 180660
CCDS
HPRD
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca