InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCSK6

Summary

InnateDB Protein

IDBP-813814.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCSK6

Protein Name

proprotein convertase subtilisin/kexin type 6

Synonyms

PACE4; SPC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000482760

InnateDB Gene

IDBG-32449 (PCSK6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008233	peptidase activity
GO:0048406	nerve growth factor binding

Biological Process

GO:0006508	proteolysis
GO:0007354	zygotic determination of anterior/posterior axis, embryo
GO:0007368	determination of left/right symmetry
GO:0009100	glycoprotein metabolic process
GO:0016485	protein processing
GO:0016486	peptide hormone processing
GO:0030510	regulation of BMP signaling pathway
GO:0032455	nerve growth factor processing
GO:0032902	nerve growth factor production
GO:0032940	secretion by cell
GO:0048011	neurotrophin TRK receptor signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005796	Golgi lumen
GO:0009986	cell surface
GO:0016020	membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000209 Peptidase S8/S53 domain
IPR000742 Epidermal growth factor-like domain
IPR002884 Proprotein convertase, P
IPR006212 Furin-like repeat
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR010909 PLAC
IPR015500 Peptidase S8, subtilisin-related

PFAM

PF00082
PF00008
PF01483
PF08686

PRINTS

PR00723

PIRSF

SMART

SM00181
SM00261

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt