Version 5.4
Homo sapiens Gene: PCSK6
Summary
InnateDB Gene IDBG-32449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCSK6
Gene Name proprotein convertase subtilisin/kexin type 6
Synonyms PACE4; SPC4
Species Homo sapiens
Ensembl Gene ENSG00000140479
Encoded Proteins
IDBP-32457
proprotein convertase subtilisin/kexin type 6
IDBP-233609
proprotein convertase subtilisin/kexin type 6
IDBP-601440
proprotein convertase subtilisin/kexin type 6
IDBP-584173
proprotein convertase subtilisin/kexin type 6
IDBP-585615
proprotein convertase subtilisin/kexin type 6
IDBP-585653
proprotein convertase subtilisin/kexin type 6
IDBP-813814
proprotein convertase subtilisin/kexin type 6
IDBP-813815
proprotein convertase subtilisin/kexin type 6
IDBP-813816
proprotein convertase subtilisin/kexin type 6
IDBP-813817
proprotein convertase subtilisin/kexin type 6
IDBP-813818
proprotein convertase subtilisin/kexin type 6
IDBP-813819
proprotein convertase subtilisin/kexin type 6
IDBP-813820
proprotein convertase subtilisin/kexin type 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:101297142-101525202
Strand Reverse strand
Band q26.3
Transcripts
ENST00000331826 ENSP00000332052
ENST00000398185 ENSP00000381246
ENST00000558864 ENSP00000452839
ENST00000558951 ENSP00000453771
ENST00000559499
ENST00000557794
ENST00000558433
ENST00000559430
ENST00000560785
ENST00000559605 ENSP00000453155
ENST00000560902
ENST00000558154
ENST00000559417 ENSP00000452997
ENST00000611716 ENSP00000482760
ENST00000618548 ENSP00000479496
ENST00000622483 ENSP00000481556
ENST00000619160 ENSP00000482831
ENST00000611967 ENSP00000477768
ENST00000615296 ENSP00000478081
ENST00000621185 ENSP00000483048
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0008233 peptidase activity
GO:0048406 nerve growth factor binding
Biological Process
GO:0006508 proteolysis
GO:0007354 zygotic determination of anterior/posterior axis, embryo
GO:0007368 determination of left/right symmetry
GO:0009100 glycoprotein metabolic process
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0030510 regulation of BMP signaling pathway
GO:0032455 nerve growth factor processing
GO:0032902 nerve growth factor production
GO:0032940 secretion by cell
GO:0048011 neurotrophin TRK receptor signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005796 Golgi lumen
GO:0009986 cell surface
GO:0016020 membrane
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030513
View Gene Order
ENSBTAG00000006675
Not yet available
Pathways
NETPATH
REACTOME
REACT_11062
NGF processing pathway
REACT_111057
Signaling by NODAL pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001291309 NM_002570 NM_138319 NM_138320 NM_138321 NM_138323 NM_138324 NM_138325
HUGO
OMIM
CCDS CCDS73789 CCDS73790 CCDS73791 CCDS73792 CCDS73793
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca