Version 5.4
Homo sapiens Protein: RNLS
Summary
InnateDB Protein IDBP-81464.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNLS
Protein Name renalase, FAD-dependent amine oxidase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361015
InnateDB Gene IDBG-81462 (RNLS)
Protein Structure
UniProt Annotation
Function Catalyzes the oxidation of the less abundant alpha- NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. {ECO:0000269PubMed:15841207, ECO:0000269PubMed:17385068}.
Subcellular Localization Secreted {ECO:0000269PubMed:15841207}.
Disease Associations
Tissue Specificity Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. {ECO:0000269PubMed:15841207}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 1 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR002937 Amine oxidase
PFAM PF01593
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5VYX0
PhosphoSite PhosphoSite-Q5VYX0
TrEMBL G9G137
UniProt Splice Variant
Entrez Gene 55328
UniGene Hs.149849
RefSeq NP_060833
HUGO HGNC:25641
OMIM 609360
CCDS CCDS7388
HPRD 07742
IMGT
EMBL AK002080 AL139406 AL353149 AL365185 BC005364 JN232199
GenPept AAH05364 AEW43431 BAA92073 CAH70340 CAH70341 CAH73628 CAH73629 CAH73711 CAH73712

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca