InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNLS

Summary

InnateDB Protein

IDBP-81466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNLS

Protein Name

renalase, FAD-dependent amine oxidase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000332530

InnateDB Gene

IDBG-81462 (RNLS)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidation of the less abundant alpha- NAD(P)H isoform to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. {ECO:0000269PubMed:15841207, ECO:0000269PubMed:17385068}.

Subcellular Localization

Secreted {ECO:0000269PubMed:15841207}.

Disease Associations

Tissue Specificity

Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. {ECO:0000269PubMed:15841207}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity

Biological Process

GO:0002931	response to ischemia
GO:0003073	regulation of systemic arterial blood pressure
GO:0003214	cardiac left ventricle morphogenesis
GO:0042414	epinephrine metabolic process
GO:0042415	norepinephrine metabolic process
GO:0042417	dopamine metabolic process
GO:0055062	phosphate ion homeostasis
GO:0055114	oxidation-reduction process
GO:0060047	heart contraction
GO:0071869	response to catecholamine
GO:0071871	response to epinephrine
GO:0071873	response to norepinephrine
GO:1902074	response to salt