InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAJB2

Summary

InnateDB Protein

IDBP-81511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJB2

Protein Name

DnaJ (Hsp40) homolog, subfamily B, member 2

Synonyms

DSMA5; HSJ-1; HSJ1; HSPF3;

Species

Homo sapiens

Ensembl Protein

ENSP00000338019

InnateDB Gene

IDBG-81509 (DNAJB2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Distal spinal muscular atrophy, autosomal recessive, 5 (DSMA5) [MIM:614881]: An autosomal recessive neurologic disorder characterized by young adult onset of slowly progressive distal muscle weakness and atrophy resulting in gait impairment and loss of reflexes due to impaired function of motor nerves. Sensation and cognition are not impaired. {ECO:0000269PubMed:22522442}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Brain (neuronal layers). Weakly, in skeletal muscle and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030544	Hsp70 protein binding
GO:0031593	polyubiquitin binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding
GO:0070628	proteasome binding

Biological Process

GO:0006457	protein folding
GO:0006986	response to unfolded protein
GO:0008219	cell death
GO:0008285	negative regulation of cell proliferation
GO:0030308	negative regulation of cell growth
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042026	protein refolding
GO:0090084	negative regulation of inclusion body assembly
GO:0090086	negative regulation of protein deubiquitination