InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRN

Summary

InnateDB Protein

IDBP-81529.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRN

Protein Name

protein tyrosine phosphatase, receptor type, N

Synonyms

IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N;

Species

Homo sapiens

Ensembl Protein

ENSP00000295718

InnateDB Gene

IDBG-81527 (PTPRN)

Protein Structure

UniProt Annotation

Function

Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. {ECO:0000269PubMed:8144912, ECO:0000269PubMed:8641276}.

Subcellular Localization

Membrane; Single-pass type I membrane protein. Note=Neuroendocrine secretory granules.

Disease Associations

Tissue Specificity

Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary. {ECO:0000269PubMed:8024693}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0030507	spectrin binding
GO:0051020	GTPase binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0006470	protein dephosphorylation
GO:0009749	response to glucose
GO:0016311	dephosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0032868	response to insulin
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0043627	response to estrogen
GO:0051591	response to cAMP

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR021613 Protein-tyrosine phosphatase receptor IA-2 ectodomain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF11548

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt