Homo sapiens Gene: PTPRN | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-81527.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PTPRN | ||||||||||||||||||
Gene Name | protein tyrosine phosphatase, receptor type, N | ||||||||||||||||||
Synonyms | IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000054356 | ||||||||||||||||||
Encoded Proteins |
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
protein tyrosine phosphatase, receptor type, N
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 2:219289623-219309648 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q35 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME | |||||||||||||||||||
KEGG |
Type I diabetes mellitus pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.715412 Hs.89655 | ||||||||||||||||||
RefSeq | NM_001199763 NM_001199764 NM_002846 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS2440 CCDS56167 CCDS56168 | ||||||||||||||||||
HPRD | 03466 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||