InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DAGLB

Summary

InnateDB Protein

IDBP-8177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAGLB

Protein Name

diacylglycerol lipase, beta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000297056

InnateDB Gene

IDBG-8175 (DAGLB)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. {ECO:0000269PubMed:14610053}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14610053}; Multi-pass membrane protein {ECO:0000269PubMed:14610053}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004806	triglyceride lipase activity
GO:0046872	metal ion binding

Biological Process

GO:0006629	lipid metabolic process
GO:0007405	neuroblast proliferation
GO:0007596	blood coagulation
GO:0016042	lipid catabolic process
GO:0019369	arachidonic acid metabolic process
GO:0022008	neurogenesis
GO:0030168	platelet activation
GO:0042136	neurotransmitter biosynthetic process