InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS3

Summary

InnateDB Protein

IDBP-81824.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS3

Protein Name

regulator of G-protein signaling 3

Synonyms

C2PA; RGP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000340284

InnateDB Gene

IDBG-81812 (RGS3)

Protein Structure

UniProt Annotation

Function

Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269PubMed:10749886, ECO:0000269PubMed:11294858, ECO:0000269PubMed:8602223, ECO:0000269PubMed:9858594}.

Subcellular Localization

Cytoplasm. Nucleus. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity