InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFIT2

Summary

InnateDB Protein

IDBP-81897.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFIT2

Protein Name

interferon-induced protein with tetratricopeptide repeats 2

Synonyms

cig42; G10P2; GARG-39; IFI-54; IFI-54K; IFI54; IFIT-2; ISG-54 K; ISG-54K; ISG54; P54;

Species

Homo sapiens

Ensembl Protein

ENSP00000360891

InnateDB Gene

IDBG-81895 (IFIT2)

Protein Structure

UniProt Annotation

Function

IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. {ECO:0000269PubMed:21190939}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21190939}. Endoplasmic reticulum {ECO:0000269PubMed:21190939}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.

Experimentally validated
Total	54 [view]
Protein-Protein	43 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0008637	apoptotic mitochondrial changes
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0032091	negative regulation of protein binding
GO:0035457	cellular response to interferon-alpha
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway