InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AMBP

Summary

InnateDB Protein

IDBP-81954.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMBP

Protein Name

alpha-1-microglobulin/bikunin precursor

Synonyms

A1M; EDC1; HCP; HI30; IATIL; ITI; ITIL; ITILC; UTI;

Species

Homo sapiens

Ensembl Protein

ENSP00000265132

InnateDB Gene

IDBG-81952 (AMBP)

Protein Structure

UniProt Annotation

Function

Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. {ECO:0000269PubMed:7676539}.Trypstatin is a trypsin inhibitor. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha- trypsin inhibitor is present in plasma and urine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	18 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0019855	calcium channel inhibitor activity
GO:0019862	IgA binding
GO:0020037	heme binding
GO:0036094	small molecule binding
GO:0042803	protein homodimerization activity
GO:0046904	calcium oxalate binding

Biological Process

GO:0007155	cell adhesion
GO:0007565	female pregnancy
GO:0010951	negative regulation of endopeptidase activity
GO:0016032	viral process
GO:0018298	protein-chromophore linkage
GO:0030163	protein catabolic process
GO:0042167	heme catabolic process
GO:0046329	negative regulation of JNK cascade
GO:0050777	negative regulation of immune response

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR002345 Lipocalin
IPR002968 Alpha-1-microglobulin
IPR002972 Prostaglandin D synthase
IPR011038 Calycin-like

PFAM

PF00061
PF08212
PF00014

PRINTS

PR00759
PR00179
PR01215
PR01254

PIRSF

SMART

SM00131

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt