InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INHA

Summary

InnateDB Protein

IDBP-81972.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INHA

Protein Name

inhibin, alpha

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000243786

InnateDB Gene

IDBG-81968 (INHA)

Protein Structure

UniProt Annotation

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female. {ECO:0000269PubMed:9506758}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0034711	inhibin binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001501	skeletal system development
GO:0001541	ovarian follicle development
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0008584	male gonad development
GO:0009605	response to external stimulus
GO:0030154	cell differentiation
GO:0030218	erythrocyte differentiation
GO:0042127	regulation of cell proliferation
GO:0042326	negative regulation of phosphorylation
GO:0042541	hemoglobin biosynthetic process
GO:0045077	negative regulation of interferon-gamma biosynthetic process
GO:0045578	negative regulation of B cell differentiation
GO:0045650	negative regulation of macrophage differentiation
GO:0045786	negative regulation of cell cycle
GO:0046881	positive regulation of follicle-stimulating hormone secretion
GO:0046882	negative regulation of follicle-stimulating hormone secretion
GO:0051726	regulation of cell cycle

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0034673	inhibin-betaglycan-ActRII complex
GO:0043025	neuronal cell body
GO:0043512	inhibin A complex

Protein Structure and Domains

PDB ID

InterPro

IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR017175 Inhibin, alpha subunit subgroup
IPR029034 Cystine-knot cytokine

PFAM

PF00019

PRINTS

PR00669

PIRSF

PIRSF037328

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References