InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: INHA

Summary

InnateDB Gene

IDBG-81968.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INHA

Gene Name

inhibin, alpha

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000123999

Encoded Proteins

IDBP-81972

inhibin, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the alpha subunit of inhibins A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion.[provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:219569162-219575713

Strand

Forward strand

Band

q35

Transcripts

ENST00000243786	ENSP00000243786
ENST00000489456

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0034711	inhibin binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001501	skeletal system development
GO:0001541	ovarian follicle development
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007399	nervous system development
GO:0008584	male gonad development
GO:0009605	response to external stimulus
GO:0030154	cell differentiation
GO:0030218	erythrocyte differentiation
GO:0042127	regulation of cell proliferation
GO:0042326	negative regulation of phosphorylation
GO:0042541	hemoglobin biosynthetic process
GO:0045077	negative regulation of interferon-gamma biosynthetic process
GO:0045578	negative regulation of B cell differentiation
GO:0045650	negative regulation of macrophage differentiation
GO:0045786	negative regulation of cell cycle
GO:0046881	positive regulation of follicle-stimulating hormone secretion
GO:0046882	negative regulation of follicle-stimulating hormone secretion
GO:0051726	regulation of cell cycle

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0034673	inhibin-betaglycan-ActRII complex
GO:0043025	neuronal cell body
GO:0043512	inhibin A complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032968

View Gene Order

ENSBTAG00000009972

Not yet available

Pathways

NETPATH

REACTOME

REACT_15398

Glycoprotein hormones pathway

REACT_15452

Peptide hormone biosynthesis pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

INOH

INOH website

GPCR signaling pathway

INOH website

TGF-beta signaling pathway

INOH website

BMP2 signaling pathway

PID NCI

Cross-References

SwissProt

P05111

TrEMBL

UniProt Splice Variant

Entrez Gene

3623

UniGene

Hs.407506

RefSeq

NM_002191

HUGO

HGNC:6065

OMIM

147380

CCDS

CCDS2444

HPRD

IMGT

EMBL

AK292340 BC006391 BT006954 CH471063 M13144 M13981 X04445 X04446

GenPept

AAA59166 AAA59167 AAH06391 AAP35600 BAF85029 CAA28040 EAW70774

RNA Seq Atlas

3623