InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC4A3

Summary

InnateDB Protein

IDBP-82063.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC4A3

Protein Name

solute carrier family 4, anion exchanger, member 3

Synonyms

AE3; SLC2C;

Species

Homo sapiens

Ensembl Protein

ENSP00000314006

InnateDB Gene

IDBG-82057 (SLC4A3)

Protein Structure

UniProt Annotation

Function

Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-).

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Both BAE3 and CAE3 are expressed in failing ventricle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005452	inorganic anion exchanger activity
GO:0008509	anion transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006820	anion transport
GO:0015701	bicarbonate transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001717 Anion exchange protein
IPR002979 Anion exchange protein 3
IPR003020 Bicarbonate transporter, eukaryotic
IPR011531 Bicarbonate transporter, C-terminal
IPR013769 Band 3 cytoplasmic domain
IPR016152 Phosphotransferase/anion transporter

PFAM

PF00955
PF07565

PRINTS

PR00165
PR01189
PR01231

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48751