InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPO11

Summary

InnateDB Protein

IDBP-82087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPO11

Protein Name

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)

Synonyms

CT35; SPATA43; TOPVIA;

Species

Homo sapiens

Ensembl Protein

ENSP00000360310

InnateDB Gene

IDBG-82085 (SPO11)

Protein Structure

UniProt Annotation

Function

Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0001541	ovarian follicle development
GO:0006259	DNA metabolic process
GO:0007129	synapsis
GO:0007131	reciprocal meiotic recombination
GO:0007141	male meiosis I
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0007292	female gamete generation
GO:0034502	protein localization to chromosome

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005694	chromosome

Protein Structure and Domains

PDB ID

InterPro

IPR002815 Spo11/DNA topoisomerase VI subunit A
IPR004084 Meiosis-specific protein Spo11
IPR004085 DNA topoisomerase VI, subunit A
IPR013048 Meiotic recombination, Spo11
IPR013049 Spo11/DNA topoisomerase VI, subunit A, N-terminal

PFAM

PF03533
PF04406

PRINTS

PR01550
PR01552
PR01551

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y5K1