InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTR7

Summary

InnateDB Protein

IDBP-82128.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR7

Protein Name

5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)

Synonyms

5-HT7;

Species

Homo sapiens

Ensembl Protein

ENSP00000277874

InnateDB Gene

IDBG-82120 (HTR7)

Protein Structure

UniProt Annotation

Function

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression. {ECO:0000269PubMed:9084407}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity

Biological Process

GO:0006939	smooth muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007210	serotonin receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007623	circadian rhythm
GO:0008015	blood circulation
GO:0042310	vasoconstriction

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001069 5-Hydroxytryptamine 7 receptor
IPR001671 Melanocortin/ACTH receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00652
PR00534

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P34969