InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACSL3

Summary

InnateDB Protein

IDBP-82225.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSL3

Protein Name

acyl-CoA synthetase long-chain family member 3

Synonyms

ACS3; FACL3; PRO2194;

Species

Homo sapiens

Ensembl Protein

ENSP00000350012

InnateDB Gene

IDBG-82223 (ACSL3)

Protein Structure

UniProt Annotation

Function

Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). {ECO:0000250, ECO:0000269PubMed:18003621}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005524	ATP binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0007420	brain development
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0014070	response to organic cyclic compound
GO:0034379	very-low-density lipoprotein particle assembly
GO:0042998	positive regulation of Golgi to plasma membrane protein transport
GO:0044539	long-chain fatty acid import
GO:0051047	positive regulation of secretion
GO:2001247	positive regulation of phosphatidylcholine biosynthetic process

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005811	lipid particle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm