Version 5.4
Homo sapiens Gene: ACSL3
Summary
InnateDB Gene IDBG-82223.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSL3
Gene Name acyl-CoA synthetase long-chain family member 3
Synonyms ACS3; FACL3; PRO2194
Species Homo sapiens
Ensembl Gene ENSG00000123983
Encoded Proteins
IDBP-82225
acyl-CoA synthetase long-chain family member 3
IDBP-246416
acyl-CoA synthetase long-chain family member 3
IDBP-295246
acyl-CoA synthetase long-chain family member 3
IDBP-389127
acyl-CoA synthetase long-chain family member 3
IDBP-389128
acyl-CoA synthetase long-chain family member 3
IDBP-596378
acyl-CoA synthetase long-chain family member 3
IDBP-590812
acyl-CoA synthetase long-chain family member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92%% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:222860934-222944639
Strand Forward strand
Band q36.1
Transcripts
ENST00000357430 ENSP00000350012
ENST00000392066 ENSP00000375918
ENST00000407441 ENSP00000385157
ENST00000413316 ENSP00000416913
ENST00000421680 ENSP00000404182
ENST00000463813
ENST00000474422
ENST00000495541
ENST00000535678 ENSP00000438342
ENST00000542810
ENST00000540115 ENSP00000441643
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0007420 brain development
GO:0007584 response to nutrient
GO:0008152 metabolic process
GO:0014070 response to organic cyclic compound
GO:0034379 very-low-density lipoprotein particle assembly
GO:0042998 positive regulation of Golgi to plasma membrane protein transport
GO:0044539 long-chain fatty acid import
GO:0051047 positive regulation of secretion
GO:2001247 positive regulation of phosphatidylcholine biosynthetic process
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005811 lipid particle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032883
View Gene Order
ENSBTAG00000017258
Not yet available
Pathways
NETPATH
REACTOME
REACT_380
Synthesis of very long-chain fatty acyl-CoAs pathway
REACT_1319
Fatty Acyl-CoA Biosynthesis pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00061
Fatty acid biosynthesis pathway
hsa00071
Fatty acid degradation pathway
hsa03320
PPAR signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655772
RefSeq NM_004457 NM_203372
HUGO
OMIM
CCDS CCDS2455
HPRD 03845
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca