InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACSL4

Summary

InnateDB Protein

IDBP-82254.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACSL4

Protein Name

acyl-CoA synthetase long-chain family member 4

Synonyms

ACS4; FACL4; LACS4; MRX63; MRX68;

Species

Homo sapiens

Ensembl Protein

ENSP00000339787

InnateDB Gene

IDBG-82250 (ACSL4)

Protein Structure

UniProt Annotation

Function

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Disease Associations

Mental retardation, X-linked 63 (MRX63) [MIM:300387]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non- syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269PubMed:11889465}. Note=The disease is caused by mutations affecting the gene represented in this entry.Alport syndrome with mental retardation, midface hypoplasia and elliptocytosis (ATS-MR) [MIM:300194]: A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, sensorineural hearing loss, mental retardation, midface hypoplasia and elliptocytosis. Note=The gene represented in this entry may be involved in disease pathogenesis.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005524	ATP binding
GO:0031957	very long-chain fatty acid-CoA ligase activity
GO:0047676	arachidonate-CoA ligase activity

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0015908	fatty acid transport
GO:0019432	triglyceride biosynthetic process
GO:0030182	neuron differentiation
GO:0030307	positive regulation of cell growth
GO:0032307	negative regulation of prostaglandin secretion
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0060136	embryonic process involved in female pregnancy
GO:0060996	dendritic spine development
GO:0070672	response to interleukin-15

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome