Version 5.4
Homo sapiens Gene: ACSL4
Summary
InnateDB Gene IDBG-82250.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSL4
Gene Name acyl-CoA synthetase long-chain family member 4
Synonyms ACS4; FACL4; LACS4; MRX63; MRX68
Species Homo sapiens
Ensembl Gene ENSG00000068366
Encoded Proteins
IDBP-82252
acyl-CoA synthetase long-chain family member 4
IDBP-82254
acyl-CoA synthetase long-chain family member 4
IDBP-475772
acyl-CoA synthetase long-chain family member 4
IDBP-484245
acyl-CoA synthetase long-chain family member 4
IDBP-482341
acyl-CoA synthetase long-chain family member 4
IDBP-476137
acyl-CoA synthetase long-chain family member 4
IDBP-482639
acyl-CoA synthetase long-chain family member 4
IDBP-480620
acyl-CoA synthetase long-chain family member 4
IDBP-481215
acyl-CoA synthetase long-chain family member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:109624244-109733403
Strand Reverse strand
Band q23
Transcripts
ENST00000348502 ENSP00000262835
ENST00000340800 ENSP00000339787
ENST00000505075
ENST00000469796 ENSP00000419171
ENST00000514500 ENSP00000423539
ENST00000505855 ENSP00000424808
ENST00000502391 ENSP00000425408
ENST00000508092 ENSP00000425378
ENST00000504980 ENSP00000421425
ENST00000469857 ENSP00000423077
ENST00000504383
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0031957 very long-chain fatty acid-CoA ligase activity
GO:0047676 arachidonate-CoA ligase activity
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0007584 response to nutrient
GO:0008152 metabolic process
GO:0008610 lipid biosynthetic process
GO:0015908 fatty acid transport
GO:0019432 triglyceride biosynthetic process
GO:0030182 neuron differentiation
GO:0030307 positive regulation of cell growth
GO:0032307 negative regulation of prostaglandin secretion
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0060136 embryonic process involved in female pregnancy
GO:0060996 dendritic spine development
GO:0070672 response to interleukin-15
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid particle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031278
View Gene Order
ENSBTAG00000018986
Not yet available
Pathways
NETPATH
REACTOME
REACT_380
Synthesis of very long-chain fatty acyl-CoAs pathway
REACT_1319
Fatty Acyl-CoA Biosynthesis pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00061
Fatty acid biosynthesis pathway
hsa00071
Fatty acid degradation pathway
hsa03320
PPAR signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RF95
UniProt Splice Variant
Entrez Gene 2182
UniGene Hs.268785
RefSeq NM_004458 NM_022977 XM_005262108 XM_005262109 XM_005262110 XM_006724635
HUGO HGNC:3571
OMIM 300157
CCDS CCDS14548 CCDS14549
HPRD 02152
IMGT
EMBL AL118496 AL138968
GenPept
RNA Seq Atlas 2182

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca