InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1R3C

Summary

InnateDB Protein

IDBP-82297.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R3C

Protein Name

protein phosphatase 1, regulatory subunit 3C

Synonyms

PPP1R5;

Species

Homo sapiens

Ensembl Protein

ENSP00000238994

InnateDB Gene

IDBG-82295 (PPP1R3C)

Protein Structure

UniProt Annotation

Function

Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. {ECO:0000250UniProtKB:Q7TMB3, ECO:0000269PubMed:8985175}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005977	glycogen metabolic process
GO:0005978	glycogen biosynthetic process
GO:0006006	glucose metabolic process
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process