InnateDB Protein
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IDBP-82305.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SERPINE2
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Protein Name
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serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
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Synonyms
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GDN; GDNPF; PI-7; PI7; PN-1; PN1; PNI;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000258405
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InnateDB Gene
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IDBG-82303 (SERPINE2)
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Protein Structure
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Function |
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
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Subcellular Localization |
Secreted, extracellular space.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
|
Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0010757
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negative regulation of plasminogen activation
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GO:0010951
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negative regulation of endopeptidase activity
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GO:0010955
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negative regulation of protein processing
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GO:0030195
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negative regulation of blood coagulation
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GO:0030334
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regulation of cell migration
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GO:0045861
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negative regulation of proteolysis
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GO:0048711
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positive regulation of astrocyte differentiation
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GO:0090331
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negative regulation of platelet aggregation
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Cellular Component |
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PDB ID |
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InterPro |
IPR023796
Serpin domain
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PFAM |
PF00079
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PRINTS |
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PIRSF |
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SMART |
SM00093
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TIGRFAMs |
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Modification |
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SwissProt |
P07093
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PhosphoSite |
PhosphoSite-P07093
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TrEMBL |
C9K031
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UniProt Splice Variant |
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Entrez Gene |
5270
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UniGene |
Hs.727245
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RefSeq |
NP_006207
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HUGO |
HGNC:8951
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OMIM |
177010
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CCDS |
CCDS2460
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HPRD |
01510
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IMGT |
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EMBL |
AC073641
AK295564
AK312499
BC015663
BC042628
CH471063
M17783
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GenPept |
AAA35883
AAH15663
AAH42628
AAY14926
BAG35401
BAG58464
EAW70821
EAW70822
EAW70823
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