InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTCFL

Summary

InnateDB Protein

IDBP-82310.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTCFL

Protein Name

CCCTC-binding factor (zinc finger protein)-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000243914

InnateDB Gene

IDBG-82306 (CTCFL)

Protein Structure

UniProt Annotation

Function

Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. {ECO:0000250, ECO:0000269PubMed:12011441, ECO:0000269PubMed:18413740, ECO:0000269PubMed:18765639}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Testis specific. Specifically expressed in primary spermatocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0042393	histone binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006349	regulation of gene expression by genetic imprinting
GO:0006351	transcription, DNA-templated
GO:0007049	cell cycle
GO:0010628	positive regulation of gene expression
GO:0016571	histone methylation
GO:0043046	DNA methylation involved in gamete generation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051569	regulation of histone H3-K4 methylation