Version 5.4
Homo sapiens Gene: CTCFL
Summary
InnateDB Gene IDBG-82306.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTCFL
Gene Name CCCTC-binding factor (zinc finger protein)-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124092
Encoded Proteins
IDBP-82308
CCCTC-binding factor (zinc finger protein)-like
IDBP-82310
CCCTC-binding factor (zinc finger protein)-like
IDBP-379258
CCCTC-binding factor (zinc finger protein)-like
IDBP-379269
CCCTC-binding factor (zinc finger protein)-like
IDBP-379276
CCCTC-binding factor (zinc finger protein)-like
IDBP-379280
CCCTC-binding factor (zinc finger protein)-like
IDBP-379282
CCCTC-binding factor (zinc finger protein)-like
IDBP-379283
CCCTC-binding factor (zinc finger protein)-like
IDBP-379286
CCCTC-binding factor (zinc finger protein)-like
IDBP-585071
CCCTC-binding factor (zinc finger protein)-like
IDBP-811675
CCCTC-binding factor (zinc finger protein)-like
IDBP-594396
CCCTC-binding factor (zinc finger protein)-like
IDBP-811647
CCCTC-binding factor (zinc finger protein)-like
IDBP-811649
CCCTC-binding factor (zinc finger protein)-like
IDBP-811653
CCCTC-binding factor (zinc finger protein)-like
IDBP-811666
CCCTC-binding factor (zinc finger protein)-like
IDBP-811670
CCCTC-binding factor (zinc finger protein)-like
IDBP-811671
CCCTC-binding factor (zinc finger protein)-like
IDBP-811674
CCCTC-binding factor (zinc finger protein)-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:57495966-57525652
Strand Reverse strand
Band q13.31
Transcripts
ENST00000371196 ENSP00000360239
ENST00000243914 ENSP00000243914
ENST00000422869 ENSP00000399061
ENST00000423479 ENSP00000415579
ENST00000429804 ENSP00000415329
ENST00000426658 ENSP00000403369
ENST00000433949 ENSP00000392034
ENST00000432255 ENSP00000409344
ENST00000422109 ENSP00000413713
ENST00000502686 ENSP00000437999
ENST00000481655 ENSP00000476577
ENST00000539382 ENSP00000439998
ENST00000608263 ENSP00000476783
ENST00000609232 ENSP00000476398
ENST00000608440 ENSP00000477488
ENST00000608903 ENSP00000476718
ENST00000608425 ENSP00000476458
ENST00000608720 ENSP00000477412
ENST00000607923
ENST00000608858
ENST00000608108
ENST00000608158 ENSP00000477165
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042393 histone binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-templated
GO:0007049 cell cycle
GO:0010628 positive regulation of gene expression
GO:0016571 histone methylation
GO:0043046 DNA methylation involved in gamete generation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051569 regulation of histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000070495
View Gene Order
ENSBTAG00000013079
Not yet available
Cross-References
SwissProt Q8NI51
TrEMBL
UniProt Splice Variant
Entrez Gene 140690
UniGene Hs.131543 Hs.742208
RefSeq NM_001269043 NM_001269040 NM_001269041 NM_001269042 NM_001269044 NM_001269045 NM_001269046 NM_001269047 NM_001269048 NM_001269049 NM_001269050 NM_001269051 NM_001269052 NM_001269054 NM_001269055 NM_080618
HUGO HGNC:16234
OMIM 607022
CCDS CCDS58780 CCDS13459 CCDS58776 CCDS58777 CCDS58778 CCDS58779 CCDS58781 CCDS58782 CCDS68161 CCDS68162 CCDS68163 CCDS68164
HPRD 09512
IMGT
EMBL AF336042 AK128070 AL035541 AL160176 AY071919 BC130486 CH471077 DQ294738 DQ778108 DQ778109 DQ778110 DQ778111 DQ778112 DQ778115 DQ778116 DQ778121 DQ778123 DQ778124 DQ778125 DQ778126 DQ778127
GenPept AAI30487 AAL61541 AAM28645 ABB92839 ABH10090 ABH10091 ABH10092 ABH10093 ABH10094 ABH10097 ABH10098 ABH10103 ABH10105 ABH10106 ABH10107 ABH10108 ABH10109 BAG54626 CAI42956 EAW75518
RNA Seq Atlas 140690

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca