InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNKS2

Summary

InnateDB Protein

IDBP-82313.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNKS2

Protein Name

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360689

InnateDB Gene

IDBG-82311 (TNKS2)

Protein Structure

UniProt Annotation

Function

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity. {ECO:0000269PubMed:11739745, ECO:0000269PubMed:11802774, ECO:0000269PubMed:19759537, ECO:0000269PubMed:21478859, ECO:0000269PubMed:23622245}.

Subcellular Localization

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere {ECO:0000305}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.

Disease Associations

Tissue Specificity

Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006471	protein ADP-ribosylation
GO:0016055	Wnt signaling pathway
GO:0032212	positive regulation of telomere maintenance via telomerase
GO:0035264	multicellular organism growth
GO:0040014	regulation of multicellular organism growth
GO:0070198	protein localization to chromosome, telomeric region
GO:0070213	protein auto-ADP-ribosylation
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0000242	pericentriolar material
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR002110 Ankyrin repeat
IPR011510 Sterile alpha motif, type 2
IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
IPR013761 Sterile alpha motif/pointed domain
IPR020683 Ankyrin repeat-containing domain
IPR021129 Sterile alpha motif, type 1

PFAM