Version 5.4
Homo sapiens Protein: SLC39A7
Summary
InnateDB Protein IDBP-82316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A7
Protein Name solute carrier family 39 (zinc transporter), member 7
Synonyms D6S115E; D6S2244E; H2-KE4; HKE4; KE4; RING5; ZIP7;
Species Homo sapiens
Ensembl Protein ENSP00000363809
InnateDB Gene IDBG-82314 (SLC39A7)
Protein Structure
UniProt Annotation
Function Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+), as well as by exogenous Zn(2+). {ECO:0000269PubMed:14525538, ECO:0000269PubMed:15705588, ECO:0000269PubMed:22317921}.
Subcellular Localization Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:14525538, ECO:0000269PubMed:15705588}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 11 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006829 zinc ion transport
GO:0030001 metal ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002395 HMW kininogen
IPR003689 Zinc/iron permease
PFAM PF02535
PRINTS PR00334
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92504
PhosphoSite PhosphoSite-Q92504
TrEMBL Q29984
UniProt Splice Variant
Entrez Gene 7922
UniGene Hs.631995
RefSeq NP_008910
HUGO HGNC:4927
OMIM 601416
CCDS CCDS43453
HPRD 09028
IMGT
EMBL AF117221 AL031228 AL645940 AL662824 AL844527 BC000645 CH471081 CR354565 CR759733 CR759786 CR936877 D82060 M58660
GenPept AAA63219 AAD12305 AAH00645 BAA11528 CAA20238 CAI17615 CAI18067 CAI41839 CAQ08249 CAQ09067 CAQ10301 CAQ11085 EAX03680 EAX03681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca